3D Bioprinting and Organ Transplantation: Patient Dream or Ethical Nightmare?
DOI:
https://doi.org/10.55613/jeet.v32i1.96Keywords:
bioprinting, tissue engineering, regenerative medicine, ethics in technologyAbstract
With the advent of recent advancements in biotechnology and digital manufacturing, organ manufacturing and transplantation has become a reality nowadays. This paper describes a detailed overview of the success and challenges of the bioprinting and organ technologies, its realization in today’s age and ethical concerns that complicates its prevalence and popularity in the society. The advances are promising and the research areas are numerous because the benefits are enormous for the patients. The technology has the potential to revolutionize the healthcare market and particularly the pharmaceutical sector by solving some key issues after going through a long and expensive process of research and development of such new treatments.
References
Ahadian, S., & Khademhosseini, A. (2018). A perspective on 3D bioprinting in tissue regeneration. Bio-design and manufacturing, 1(3), 157-160.
Arif, Z. U., Khalid, M. Y., Ahmed, W., & Arshad, H. (2022). A review on four-dimensional bioprinting in pursuit of advanced tissue engineering applications. Bioprinting, e00203.
Beauchamp, T. L., Beauchamp, T. A., & Childress, J. F. (1994). Principles of biomedical ethics: Edicoes Loyola.
Cao, X., Maharjan, S., Ashfaq, R., Shin, J., & Zhang, Y. S. (2021). Bioprinting of small-diameter blood vessels. Engineering, 7(6), 832-844.
Combellack, E., Jessop, Z., & Whitaker, I. (2018). The commercial 3D bioprinting industry 3D Bioprinting for Reconstructive Surgery (pp. 413-421): Elsevier.
Cui, H., Nowicki, M., Fisher, J. P., & Zhang, L. G. (2017). 3D bioprinting for organ regeneration. Advanced healthcare materials, 6(1), 1601118.
Datta, P., Ayan, B., & Ozbolat, I. T. (2017). Bioprinting for vascular and vascularized tissue biofabrication. Acta biomaterialia, 51, 1-20.
Dey, M., & Ozbolat, I. T. (2020). 3D bioprinting of cells, tissues and organs: Nature Publishing Group.
Dukanovic, A. (2021). Regulation of Reproductive Cloning and Inheritable Genetic Modifications on Humans-Perils and Deficiencies. J. Crimin. & Crim. L., 59, 23.
Esworthy, T. J., Miao, S., Lee, S.-J., Zhou, X., Cui, H., Zuo, Y. Y., & Zhang, L. G. (2019). Advanced 4D-bioprinting technologies for brain tissue modeling and study. International journal of smart and nano materials, 10(3), 177-204.
Fazal, F., Raghav, S., Callanan, A., Koutsos, V., & Radacsi, N. (2021). Recent advancements in the bioprinting of vascular grafts. Biofabrication.
Gilbert, F., O’Connell, C. D., Mladenovska, T., & Dodds, S. (2018). Print me an organ? Ethical and regulatory issues emerging from 3D bioprinting in medicine. Science and engineering ethics, 24(1), 73-91.
Gu, Z., Fu, J., Lin, H., & He, Y. (2020). Development of 3D bioprinting: From printing methods to biomedical applications. Asian Journal of Pharmaceutical Sciences, 15(5), 529-557.
Humphreys, B. D. (2021). Bioprinting better kidney organoids. Nature Materials, 20(2), 128-130.
Iram, D., a Riaz, R., & Iqbal, R. K. (2019). 3D Bioprinting: An attractive alternative to traditional organ transplantation. Biomed Sci Eng, 5(1), 007-018.
Kirillova, A., Bushev, S., Abubakirov, A., & Sukikh, G. (2020). Bioethical and legal issues in 3D bioprinting. International Journal of Bioprinting, 6(3).
Lo, B., & Parham, L. (2009). Ethical issues in stem cell research. Endocrine reviews, 30(3), 204-213.
Lu, S. Y. F., & Groh, A. M. (2022). 3D bioprinting in microgravity: An end to organ donor shortages? STEM Fellowship Journal, 7(2), 25-28.
Matthews, N., Pandolfo, B., Moses, D., & Gentile, C. (2022). Taking It Personally: 3D Bioprinting a Patient-Specific Cardiac Patch for the Treatment of Heart Failure. Bioengineering, 9(3), 93.
Moghaddam, A. S., Khonakdar, H. A., Arjmand, M., Jafari, S. H., Bagher, Z., Moghaddam, Z. S., . . . Shojaei, S. (2021). Review of Bioprinting in Regenerative Medicine: Naturally Derived Bioinks and Stem Cells. ACS Applied Bio Materials, 4(5), 4049-4070.
Moldovan, F. (2019). Recent trends in bioprinting. Procedia Manufacturing, 32, 95-101.
Oliveira, E. P., Malysz-Cymborska, I., Golubczyk, D., Kalkowski, L., Kwiatkowska, J., Reis, R. L., . . . Walczak, P. (2019). Advances in bioinks and in vivo imaging of biomaterials for CNS applications. Acta biomaterialia, 95, 60-72.
Pal, A. (2022). Cloning Protocols in Advanced Genomics and Allied Techniques (pp. 81-93): Springer.
Pountos, I., Tellisi, N., & Ashammakhi, N. (2019). Three-Dimensional Bioprinting: Safety, Ethical, and Regulatory Considerations 3D Bioprinting in Medicine (pp. 191-203): Springer.
Qiu, B., Bessler, N., Figler, K., Buchholz, M. B., Rios, A. C., Malda, J., . . . Caiazzo, M. (2020). Bioprinting neural systems to model central nervous system diseases. Advanced Functional Materials, 30(44), 1910250.
Smarttech. (2021). SmarTech Issues New 3D Printing Report That Projects Bioprinting Revenues to Reach $1.1 billion in Revenues in 2027. Retrieved Oct 1, 2021, from https://www.smartechanalysis.com/news/market-report-bioprinting-2027/
Sumant Ugalmugle, & Swain, R. (2020). Artificial Organ Market (2020-26) (pp. 1-101).
Tomasina, C., Bodet, T., Mota, C., Moroni, L., & Camarero-Espinosa, S. (2019). Bioprinting vasculature: materials, cells and emergent techniques. Materials, 12(17), 2701.
Tong, A., Pham, Q. L., Abatemarco, P., Mathew, A., Gupta, D., Iyer, S., & Voronov, R. (2021). Review of low-cost 3D bioprinters: State of the market and observed future trends. SLAS TECHNOLOGY: Translating Life Sciences Innovation, 26(4), 333-366.
Varkey, M., & Atala, A. (2015). Organ bioprinting: a closer look at ethics and policies. Wake Forest JL & Pol'y, 5, 275.
Vermeulen, N., Haddow, G., Seymour, T., Faulkner-Jones, A., & Shu, W. (2017). 3D bioprint me: a socioethical view of bioprinting human organs and tissues. Journal of Medical Ethics, 43(9), 618-624.
Vijayavenkataraman, S., Lu, W., & Fuh, J. Y. H. (2016). 3D bioprinting–an ethical, legal and social aspects (ELSA) framework. Bioprinting, 1, 11-21.
Vijayavenkataraman, S., Yan, W.-C., Lu, W. F., Wang, C.-H., & Fuh, J. Y. H. (2018). 3D bioprinting of tissues and organs for regenerative medicine. Advanced drug delivery reviews, 132, 296-332.
Zhang, X., Peng, Y., & Zou, K. (2018). Germline stem cells: a useful tool for therapeutic cloning. Current Stem Cell Research & Therapy, 13(4), 236-242.
Downloads
Published
Issue
Section
License
Copyright (c) 2022 Zeashan Khan, Dr Afifa Siddique
This work is licensed under a Creative Commons Attribution 4.0 International License.
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International license (CC-BY 4.0) that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are encouraged to post their work online (e.g., in institutional repositories or on their website) after publication, while providing bibliographic details that credit JEET (See The Effect of Open Access).
How to Cite
