Polarizing Biotechnologies and a Polarized Public

New Challenges for Global Calls for Public Engagement in Human Genome Editing

Authors

  • Oliver Feeney University of Tübingen

DOI:

https://doi.org/10.55613/jeet.v35i2.168

Keywords:

Genome editing, public engagement, socio-political polarization, genobility, liberal democracy

Abstract

The rapid advancements in genome editing, particularly with CRISPR-Cas9, have brought long-promised medical breakthroughs to reality, but also has also accelerated ethically fraught applications. To develop adequate ethical safeguards and effective governance, many endorse public engagement as an essential aspect of this response. This paper tests this confidence by applying it to an emerging existential risk that this rapid development of genome editing, when combined with similarly rapidly growing socio-political polarisation, poses to liberal democracy. While this argument has some echoes of Maxwell Mehlman’s spectre of a genetically enhanced "genobility" destroying the basis of liberal democracy, I outline how this new concern is more plausible, more immediate and, moreover, possibly far more intractable a problem than Mehlman was considering. This is exacerbated by considering how the perception of genome editing’s potential—rather than its actual capabilities—may be affected by and, in turn, may worsen this rising socio-political polarisation. Given the confidence in the positive role of public engagement with respect to the technology that is involved here, I evaluate its effectiveness, arguing that certain forms of engagement may inadvertently worsen things, whereas stronger deliberative approaches hold promise but face significant, potentially insurmountable, barriers, at least for now.

References

1. Andorno, R., Baylis, F., Darnovsky, M., et al. (2020) Geneva Statement on Heritable Human Genome Editing: The Need for Course Correction. Trends in Biotechnology, April 2020, Vol. 38, No. 4.

2. Baylis, Françoise Marcy Darnovsky, Katie Hasson, and Timothy M. Krahn. Human Germline and Heritable Genome Editing: The Global Policy Landscape. The CRISPR Journal. Oct 2020.365-377. http://doi.org/10.1089/crispr.2020.0082

3. Caplan, B. (2008 ) ‘The totalitarian threat’. In N. Bostrom, M. M. Cirkovic (eds) Global Catastrophic Risks. Oxford University Press: New York.

4. Conley, J. M., Cadigan, R. J., Davis, A. M., Juengst, E. T., Kuczynski, K., Major, R., Stancil, H., Villa-Palomino, J., Waltz, M., & Henderson, G. E. (2023). The Promise and Reality of Public Engagement in the Governance of Human Genome Editing Research. The American journal of bioethics : AJOB, 23(7), 9–16. https://doi.org/10.1080/15265161.2023.2207502

5. Cyranoski, David (2019) ‘The CRISPR-baby scandal: what’s next for human gene-editing’ Nature 566 (February 2019), 440-442.

6. Curato, N., Dryzek, J. S., Ercan, S. A., Hendriks, C. M., Niemeyer S.; Twelve Key Findings in Deliberative Democracy Research. Daedalus 2017; 146 (3): 28–38. doi: https://doi.org/10.1162/DAED_a_00444

7. Feeney, O. (2022). Reasonable Trust through Deliberative Engagement: The Cases of Vaccines and Genome Editing. Social Epistemology, 36(1), 111–116. https://doi.org/10.1080/02691728.2021.2009590

8. Feeney, O. Editing the Gene Editing Debate: Reassessing the Normative Discussions on Emerging Genetic Technologies. Nanoethics 13, 233–243 (2019). https://doi.org/10.1007/s11569-019-00352-

9. Feeney, O., Borry, P., Felzmann, H., Galvagni, L., Haukkala, A., Loi, M., Nordal, S., Rakic, V., Riso, B., Sterckx, S., & Vears, D. (2018). Genuine participation in participant-centred research initiatives: the rhetoric and the potential reality. Journal of community genetics, 9(2), 133–142. https://doi.org/10.1007/s12687-017-0342-4

10. Feeney, O. (2010). Germ-line Enhancements, Inequalities and the (In)egalitarian Ethos. Studies in Ethics, Law, and Technology, 4(2). https://doi.org/10.2202/1941-6008.1122

11. Fukuyama, F. (2002). Our posthuman future: consequences of the biotechnology revolution. 1st Picador ed. New York, Picador.

12. Gormley-Heenan, C. (2007). Political Leadership and the Northern Ireland Peace Process. St Antony’s Series. Palgrave Macmillan, London.

13. Gregory, A (2024) UK toddler has hearing restored in world first gene therapy trial. The Guardian newspaper (9 May 2024): https://www.theguardian.com/science/article/2024/may/09/uk-toddler-has-hearing-restored-in-world-first-gene-therapy-trial

14. Habermas, J. (2023). A new structural transformation of the public sphere and deliberative politics. John Wiley & Sons.

15. Herzog, B. (2021). Can the Excluded Criticize? On the (Im)possibilities of Formulating and Understanding Critique. Social Epistemology, 36(1), 9–20. https://doi.org/10.1080/02691728.2021.1893858

16. Jinek, M., K. Chylinski, I. Fonfara, M. Hauer, J. A. Doudna, and E. Charpentier. 2012. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science (New York, N.Y.) 337(6096): 816–821

17. Kass, L. R. Foreword to Beyond Therapy: Biotechnology and the Pursuit of Happiness (Washington: President's Council on Bioethics, 2003).

18. Kerr, J., Panagopoulos, C., & van der Linden, S. (2021). Political polarization on COVID-19 pandemic response in the United States. Personality and individual differences, 179, 110892. https://doi.org/10.1016/j.paid.2021.110892;

19. Ledford, Heidi (2024) ‘CRISPR genome-editing grows up: advanced therapies head for the clinic’

20. Nature (news) 17 December 2024: https://www.nature.com/articles/d41586-024-04102-w

21. Ledford, Heidi (2023) ‘CRISPR 2.0: a new wave of gene editors heads for clinical trials’ Nature (news) 7 December 2023: https://www.nature.com/articles/d41586-023-03797-7

22. Lorenzo, D., Esquerda, M., Palau, F. et al. Ethics and Genomic Editing Using the Crispr-Cas9 Technique: Challenges and Conflicts. Nanoethics 16, 313–321 (2022). https://doi.org/10.1007/s11569-022-00425-y

23. Madon, S., Guyll, M., Spoth, R., & Willard, J. (2004). Self-Fulfilling Prophecies: The Synergistic Accumulative Effect of Parents’ Beliefs on Children’s Drinking Behavior. Psychological Science, 15(12), 837–845. https://doi.org/10.1111/j.0956-7976.2004.00764.x

24. Manstead, A.S.R. (2018), The psychology of social class: How socioeconomic status impacts thought, feelings, and behaviour. Br. J. Soc. Psychol., 57: 267-291. https://doi.org/10.1111/bjso.12251.

25. Mehlman, Maxwell J. (2003). Wondergenes: Genetic Enhancement and the Future of Society Bloomington: Indiana University Press

26. Nuffield Council on Bioethics (2018) Genome Editing and Human Reproduction: social and ethical issues (London: Nuffield Council on Bioethics)

27. Oliver, D. 2019. “Vaccination Sceptics are Immune to Debate.” BMJ 365: l2244. doi:10.1136/bmj.l2244.

28. Roblain, A. & Green, E. G. T. (2021). From perceived polarization of immigration attitudes to collective action. International Journal of Intercultural Relations, 80 (November 2020), 112-120. https://doi.org/10.1016/j.ijintrel.2020.11.009.

29. Smith, E.K., Bognar, M.J. & Mayer, A.P. Polarisation of Climate and Environmental Attitudes in the United States, 1973-2022. npj Clim. Action 3, 2 (2024).

30. Stein, Rob, 2021 First sickle cell patient treated with CRISPR gene-editing still thriving. npr.

31. Sparrow R. (2016). Human enhancement for whom?, in The Ethics of Human Enhancement: Understanding the Debate. Eds. Clarke S., Savulescu J., Coady T., Giubilini A., Sanyal S. (Oxford: Oxford University Press; ), 127–142. 10.1093/acprof:oso/9780198754855.003.0009

32. Visscher, P.M., Gyngell, C., Yengo, L. et al. Heritable polygenic editing: the next frontier in genomic medicine?. Nature 637, 637–645 (2025). https://doi.org/10.1038/s41586-024-08300-4

33. WHO Expert Advisory Committee on Developing Global Standards for Governance and Oversight of Human Genome Editing (2021) Human genome editing: Recommendations. World Health Organization.

34. Woolley JP, McGowan M, Harriet JAT, Coathup V, Fishman JR, Settersten RA Jr, et al. Citizen science or scientific citizenship? Disentangling the uses of public engagement rhetoric in national research initiatives. BMC Medical Ethics 2016;17(1):33.

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Published

2025-03-10

Issue

Section

Special Issue: Existential Threats and Other Disasters

How to Cite

Polarizing Biotechnologies and a Polarized Public: New Challenges for Global Calls for Public Engagement in Human Genome Editing. (2025). Journal of Ethics and Emerging Technologies, 35(2), 1-9. https://doi.org/10.55613/jeet.v35i2.168

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